Alcoholic neuropathy: MedlinePlus Medical Encyclopedia
The hyperalgesia was acutely attenuated by intradermal injection of nonselective PKC or selective PKCε inhibitors injected at the site of nociceptive testing. Miyoshi et al. [15] found that a significant decrease in the mechanical nociceptive threshold was observed after 5 weeks of chronic ethanol consumption in rats. Injection of (S)-2,6-diamino-N-[[1-(oxotridecyl)-2-piperidinyl]methyl] hexanamide dihydrochloride (NPC15437), a selective …
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